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Ambient-Temperature, Metal-Free, CDI-Mediated Ex-Situ Conversion of Acids to Amides: A Useful Late-Stage Strategy

Manisha A. Patel,Anant R. Kapdi

Chemistry, an Asian journal（2023）

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Abstract
An efficient ex-situ method for the amidation of carboxylic acids mediated by CDI has been disclosed herewith. This metal-free strategy is performed at ambient temperature and can be applied effectively for late-stage modification of amino acids and APIs.
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amides,acids
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