Alanine Scanning of the Unstructured Region of Ara h 2 and of a Related Mimotope Reveals Critical Amino Acids for IgE Binding.

Nicole Canon,Catherine H Schein,Werner Braun,Surendra S Negi,Xueni Chen,Michael D Kulis,Edwin H Kim, Vidya Pathy,Marina Pozzoli, Weimin Liu,Stephen C Dreskin

Molecular nutrition & food research（2023）

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摘要

IgE from pooled sera and individual sera differentially bound amino acids throughout the sequences of Epitope 3 and its mimotope, with Y10 and h12 being most important for all sera. These results are highly significant for designing hypoallergenic forms of Ara h 2.

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关键词

critical amino acids,ige binding,related mimotope

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