Dosimetric analysis of 17 cardiac Sub-structures, Toxicity, and survival in ultra central lung tumor patients treated with SBRT

Maiwand Ahmadsei, Kai Thaler, Elena Gasser,Bertrand Pouymayou,Riccardo Dal Bello,Sebastian M. Christ,Jonas Willmann,Boldizsar Kovacs,Panagiotis Balermpas,Stephanie Tanadini-Lang,Ardan M. Saguner,Michael Mayinger,Nicolaus Andratschke,Matthias Guckenberger

Clinical and Translational Radiation Oncology（2023）

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摘要

•Data on cardiac toxicity after SBRT for ultra-central lung tumors remains limited.•We analyzed the dose to 18 cardiac sub-structures and cardiovascular toxicity.•A SBRT regimen of 45 Gy in 8-10 fractions yields good local control and low toxicity.•The highest cardiac doses were observed in the pulmonary artery and left atrium.•Higher doses to the base of the heart seem to be associated with non-cancer deaths.

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关键词

SBRT,Cardiac toxicity,Ultra-central lung tumors,Cardiac sub-structures,Stereotactic body radiotherapy

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