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Combining Olaparib and Ascorbic Acid on Nanoparticles to Enhance the Drug Toxic Effects in Pancreatic Cancer.

Francisco Quiñonero,Belén Parra-Torrejón,Gloria B Ramírez-Rodríguez,Victor Garcés,José M Delgado-López,Cristina Jiménez-Luna,Gloria Perazzoli,Consolación Melguizo,Jose Prados,Raul Ortíz

International journal of nanomedicine（2023）

Cited 0|Views17
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Abstract
Calcium phosphate NPs, a highly biocompatible and biodegradable system, were an ideal vector for the OLA and AA co-treatment in PC, inducing significant therapeutic benefits relative to free OLA, including cytotoxicity, induction of apoptosis, inhibition of cell migration, tumor growth, and survival.
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nanomedicine, calcium phosphate nanocarriers, Olaparib, ascorbic acid, synergistic effect, pancreatic cancer
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