JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication

Xu Kong, Zuofeng Liu,Ruyi Zhang, Fu’an Xie, Rubing Liang, Yong Zhang, Lingling Yu,Wensheng Yang,Xi Li, Qiang Chen,Bei Li,Yilin Hong,Ming Li,Xiaogang Xia,Lingwei Gu,Lijuan Fu,Xiaohua Li,Ye Shen,Ting Wu,Chundong Yu

JHEP reports : innovation in hepatology（2023）

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Abstract

•JMJD2D promotes HBV transcription and replication by stabilising HBx protein.•JMJD2D sustains HBx protein stability by suppressing the TRIM14-modulated ubiquitin-proteasome degradation pathway.•JMJD2D cooperates with HBx to drive cccDNA transcription by demethylating H3K9me3 and antagonising the repressive activity of p53.•Knockdown of JMJD2D or 5C-8-HQ-mediated-JMJD2D inhibition effectively suppresses HBV replication in vitro and in vivo.

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Key words

Chronic hepatitis B,HBV replication,cccDNA transcription,JMJD2D,HBx,Intervention target

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