Virologic Studies in COVID-Positive Donors

Purpose of Review The demand and supply disparity of solid organs is a vital issue affecting the survival of patients with advanced organ failures. The COVID-19 pandemic resulted in millions of deaths leading to an enormous amount of potentially transplantable organs. However, due to knowledge gap on safety of these solid organs, tons of them were discarded. This review helps to understand important clinical aspects of solid organ transplantation from COVID + donors. Recent Findings Transplantation of solid organs from COVID + donors are safe and effective with excellent short-term outcomes and can potentially result in reduction of mortality in patients with advanced organ dysfunctions. Summary This review focuses on epidemiology, center norms, safety, short-term clinical outcomes, and the need to understand long-term clinical outcomes, including allograft functions, risk of rejections, coinfections, and immune changes toward future COVID infections in the setting of solid organ transplant from COVID-19-positive donors with the potential presence of inactive viral proteins.