Modeling human anti-pig xenoimmune responses in a pig artery tissue grafted humanized mouse model.
Xenotransplantation（2023）
Abstract
We have developed a humanized mouse model to evaluate human anti-pig xenoimmune responses by PAT transplantation in vivo. This model is expected to facilitate the refinement of pig gene-editing strategies (the expression on EC surface) and the testing of local immunosuppressive strategies for clinical pig organ xenotransplantation.
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Key words
artery, endothelial cells, humanized mice, rejection, xenotransplantation
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