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Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.

Man-Ru Liu,Ce Shi,Qiu-Ya Song,Meng-Jie Kang, Xin Jiang, Hui Liu,Dong-Sheng Pei

Hepatology communications（2023）

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Abstract
Sorafenib facilitated the TRIM54-mediated FSP1 ubiquitination through the ERK pathway, thereby inducing ferroptosis in HCC cells.
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Key words
fsp1 ubiquitination,hepatocellular carcinoma,ferroptosis
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