Salvia dumetorum essential oil: GC-MS analysis, antibacterial activity and effect on the formation of Streptococcus mutans biofilms.

essential oil (SDEO) was obtained using a Clevenger apparatus by hydrodistillation approach. The chemical composition of the essential oil was determined by GC-MS analysis. In this study SDEO was screened for its antibacterial activity against , , and and the amount of biofilm formed by bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against and and also demonstrated an inhibitory effect on biofilm formation on 1% sucrose medium. During the study, no antibacterial activity was detected against and . These results demonstrated that SDEO can be used in the development of new antibacterial and anti-caries therapeutic dental products.