Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus .

Michael Battaglia,Alex C Sunshine,Wei Luo,Richard Jin,Alifa Stith,Matt Lindemann,Lloyd S Miller,Satrajit Sinha,Elizabeth Wohlfert,Lee Ann Garrett-Sinha

Frontiers in immunology（2023）

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摘要

Our studies suggest that loss of IL-17 signaling can result in enhanced autoimmunity in Ets1 deficient autoimmune-prone mice. In addition, defects in wound healing, such as that caused by loss of DETC, can cooperate with impaired IL-17 responses to lead to increased susceptibility to skin staph infections.

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关键词

autoimmunity, immunodeficiency, Staphylococcus aureus, autoantibodies, ETS1, IL17RA, dendritic epidermal T cell

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