Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice.

Felicia Reed,Alex Reichenbach,Harry Dempsey,Rachel E Clarke,Mathieu Mequinion,Romana Stark,Sasha Rawlinson,Claire J Foldi,Sarah H Lockie,Zane B Andrews

Molecular metabolism（2023）

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摘要

Our results suggest that AgRP neurons regulate the acquisition of CIF when the acute inhibition of AgRP activity is temporally matched to context exposure. These results establish acute AgRP inhibition as a salient neural event underscoring the effect of hunger on associative learning.

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关键词

AgRP neurons, Photometry, Optogenetics, Chemogenetics, Hunger, Conditioning

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