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Convergent insights into intratumor heterogeneity

Claudia Manini,Annick Laruelle,Andre Rocha, Jose I. Lopez

TRENDS IN CANCER（2024）

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Abstract
Mathematics, conventional histology, and genomics converge to confirm that highly aggressive clear cell renal cell carcinomas (CCRCCs) display low levels of intratumor heterogeneity (ITH). We hypothesize that therapeutic strategies aimed at maintaining high ITH levels would be advisable to slow down cancer evolution and to improve survival.
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