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Pre-XDR Congenital Tuberculosis in an Extremely Premature Baby

Alison Boast, Jeu Ann How, Charis Lau,Arun Sett, Damien Gilby,Andrew Burke, Brett McWhinney, Connor Wright,Adrian Tramontana,Maria Globan,Justin Denholm,Stephen M. Graham,Joshua Osowicki

CLINICAL INFECTIOUS DISEASES（2024）

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Abstract
We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including bedaquline and delamanid, drugs not previously described in the treatment of congenital tuberculosis (TB).
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Key words
congenital tuberculosis,multidrug resistant,premature,neonate,therapeutic drug monitoring
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