Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment-resistant schizophrenia receiving clozapine: A 1-year retrospective cohort study.

Masaru Tsukahara,Ryuhei So,Yusaku Yoshimura,Rieko Yamashita,Yuji Yada,Masafumi Kodama,Shinichiro Nakajima,Yoshiki Kishi, Toshihiko Takeda,Norihito Yamada,Hiroyoshi Takeuchi

Acta psychiatrica Scandinavica（2023）

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摘要

The findings suggest that the combination of smoking habits and concomitant VPA use may increase the risk of relapse after discharge. Future studies are required to elucidate the mechanisms underlying these findings, such as a decrease in clozapine blood levels.

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clozapine, maintenance treatment, relapse, smoking, treatment-resistant schizophrenia, valproic acid

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