Phase 1b safety and pharmacokinetics of intravenous and oral fosmanogepix in patients with acute myeloid leukaemia and neutropenia.

Oliver A Cornely,Helmut Ostermann,Philipp Koehler,Daniel Teschner, Endrik Limburg,William G Kramer,Sara H Barbat,Margaret Tawadrous,Michael R Hodges

The Journal of antimicrobial chemotherapy（2023）

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摘要

Fosmanogepix was safe and well tolerated in AML patients with neutropenia receiving remission induction chemotherapy. Safety and PK profiles were comparable to healthy volunteers.

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关键词

acute myeloid leukaemia,oral fosmanogepix,pharmacokinetics,neutropenia

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