Dutch score relevance for assessing the probability of familial hypercholesterolemia diagnosis

Background and Aims: Familial hypercholesterolemia (FH) is a monogenic genetic disorder caused by mutations altering the clearance of LDL-cholesterol (LDLc) and associated with accelerated atherosclerosis. FH screening in his heterozygous form (hetFH) is based on scores combining clinics and biologicals items. In France, we usually used the « Dutch-score ». The aim of our study was to evaluate the relevance of the Dutch-score to predict the risk of being hetHF and to identify new parameters that could be added in this diagnosis.