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Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol

K. Van Kuijk, I. Mccracken, R. Tillie, S. Asselberghs, D. Kheder, S. Muitjens, H. Jin,R. Taylor,R. Wichers Schreur,C. Kuppe,R. Dobie,P. Ramachandran,M. Gijbels,L. Temmerman,P. Kirkwood,J. Luyten,Y. Li,H. Noels,P. Goossens,J. Wilson-Kanamori

Atherosclerosis（2023）

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Abstract
Background and Aims: As current markers are unable to distinguish adventitial fibroblasts from other vascular cells, we investigated their transcriptome to reveal cell type markers, heterogeneity, and regulation by cardiovascular disease (CVD) risk factors.
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Key words
serum cholesterol,fibroblast heterogeneity,single-cell,rna-sequencing
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