PPAR-Α agonist fenofibrate and 11,12-epoxyeicosatrienoic acid suppresses endoplasmic reticulum stress-induced apoptosis and enhances cell viability in diabetic rat hearts

Background and Aims: Diabetes mellitus (DM) is associated with an increased risk of cardiovascular diseases, which is related with prolonged endoplasmic reticulum (ER) stress and the activation of apoptotic pathways. Cytochrome P450 (CYP) and its arachidonic acid metabolites 11,12-epoxyeicosatrienoic acid (11,12-EET) have protective roles in heart failure by protecting endothelial cells and myocytes from apoptosis. However, the link between cardioprotective roles of CYP epoxygenase and ER stress has not been well known in diabetic cardiomyopathy. Therefore, we investigate the effects of CYP2J3 and 11,12-EET on ER stress-induced diabetic cardiomyopathy.