Engineering TALE-linked Deaminases to Facilitate Precision Adenine Base Editing in Mitochondrial DNA

Sung-Ik Cho,Kayeong Lim,Seongho Hong,Jaesuk Lee,Annie Kim, Chae Jin Lim, Seungmin Ryou,Ji Min Lee,Young Geun Mok,Eugene Chung,Sanghun Kim, Seunghun Han,Sang-Mi Cho, Jieun Kim,Eun-Kyoung Kim,Ki-Hoan Nam, Yeji Oh,Minkyung Choi,Tae Hyeon An, Kyoung-Ji Oh,Seonghyun Lee,Hyunji Lee,Jin-Soo Kim

Cell（2024）

引用 7|浏览23

关键词

mitochondria,Leigh syndrome,TALE-linked adenine deaminase,TALED,CRISPR-adenine base editor,genetic disease,in vivo genome editing,RNA off-target,mtDNA,mitochondrial genome editing

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