Enhanced Osteogenic Activity and Bone Repair Ability of PLGA/MBG Scaffolds Doped with ZIF-8 Nanoparticles Loaded with BMP-2.

Rui Ma,Yanwen Su,Ruomu Cao,Kunzheng Wang,Pei Yang

International Journal of Nanomedicine（2023）

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摘要

The PLGA/MBG/ZIF-8/BMP-2 porous scaffold could continuously and slowly release BMP-2, enhance osteogenic activity, and promote new bone formation and bone repair at bone defects. The PMZB scaffold can be used as a bone graft material to repair bone defect at non-weight-bearing sites.

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关键词

bone repair, controlled release, zeolitic imidazolate frameworks-8, mesoporous bioactive glass, scaffold

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