Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension.

Natalia J Braams,Azar Kianzad,Jessie van Wezenbeek,Jeroen N Wessels,Samara M A Jansen,Stine Andersen,Anco Boonstra,Esther J Nossent,J Tim Marcus,Ahmed A Bayoumy,Clarissa Becher,Marie-José Goumans,Asger Andersen, Anton Vonk Noordegraaf,Frances S de Man,Harm Jan Bogaard,Lilian J Meijboom

Circulation. Heart failure（2023）

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Abstract

Although cellular hypertrophy regresses and diastolic stiffness normalizes after PEA, a relative increase in extracellular volume remains. Incomplete regression of diffuse RV interstitial fibrosis after PEA is accompanied by elevated levels of circulating collagen biomarkers, suggestive of active collagen turnover.

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Key words

extracellular volume, magnetic resonance imaging, pulmonary hypertension, right ventricular function, vascular diseases, ventricular remodeling

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