Glycolytic reprogramming in macrophages and MSCs during inflammation.

Xueping Li,Huaishuang Shen,Mao Zhang,Victoria Teissier,Ejun Elijah Huang,Qi Gao,Masanori Tsubosaka,Masakazu Toya,Junichi Kushioka,Chima V Maduka,Christopher H Contag,Simon Kwoon-Ho Chow,Ning Zhang,Stuart B Goodman

Frontiers in immunology（2023）

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摘要

This study demonstrated the dysfunctional bioenergetic activity of bone marrow-derived Mφ and MSCs exposed to cPE, which could impair the immunoregulatory properties of cells in the bone niche. The underlying molecular defect related to disordered mitochondrial function could represent a potential therapeutic target during the resolution of inflammation.

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关键词

glycolytic reprogramming,macrophages,inflammation

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