The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression.

Julius Sinning, Nils David Funk,Inga Soerensen-Zender,Vera Christine Wulfmeyer,Chieh Ming Liao,Hermann Haller,Christian Hinze,Kai Martin Schmidt-Ott,Anette Melk,Roland Schmitt

Frontiers in immunology（2023）

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摘要

Together, these data suggest that during normal renal aging tubular cells activate a program of 'tubuloinflammaging', which might contribute to age-related phenotypical changes and to increased disease susceptibility.

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关键词

aging kidney,senescence,tubular cell,epithelial cell,inflammation,MHC-II

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