Dapoxetine versus glans penis injection with hyaluronic acid gel in treatment of premature ejaculation

Objectiveto compare the results of using Dapoxetine and HA (hyaluronic acid) gel injection by Five puncture technique in the treatment of premature ejaculation (PE).Methods100 sexually active heterosexuals circumcised males with lifelong PE were included in the study. Group A patients were treated with on-demand Dapoxetine, while group B was treated with HA gel glans penis injection using a five-puncture technique. Both groups were evaluated at 1(st),3(rd) and 6(th) months post-treatment using IELT.ResultsThere were no significant differences between both groups regarding patient demographic. Mean pretreatment IELT in groups A and B were 45.82 & PLUSMN; 7.44 and 46.18 & PLUSMN; 7.82 receptively. There was no significant difference between both groups. After treatment, both groups show significant ILET improvement during the 1(st),3(rd), and 6(th) months follow-up with a P value < 0.001. However, when comparing the improvement of ILET in group A (Dapoxetine) and group B (HA injection), there were high significance differences in favor of group B in the 1st,3rd, and 6th-month follow-up.ConclusionAlthough both treatment modalities have improved IELT and premature ejaculation, but HA injection with five punctures technique was significantly better than oral Dapoxetine with self-limited side effects.