Cancer and vaccines. Present and future br

Introduction. In the last century, vaccines have been the most effective public health tool to reduce mortality and morbidity from infectious diseases. In cancer prevention and treatment, the current trend is towards personalized treatment, including vaccines along with other novel treatments such as immunotherapy.Methodology. A literature review was carried out in December 2022 in the PubMed/Medline databases of scientific articles published online to date, without limiting the search period, using the following keywords and MeSH terms: cancer and vaccines; Cancer and therapeutic vaccines; colorectal cancer, Skin cancer, Breast cancer, Prostate cancer, Kidney cancer, Lung cancer; Cancer and preventive vaccines HPV, Hepatitis B.Results. The results obtained in the search with the generic concept (cancer and vaccines) and, specifically, those related to the therapeutic use of vaccines in cancer almost double those referring to preventive use. The references to lung, skin and breast cancer and, in preventive use, those for papillomavirus and hepatitis B stand out.Conclusion. The development of vaccines for cancer treatment is challenging, as vaccine intervention must combat an immune system that has been constrained by mechanisms that sustain the immune response and held back by those that maintain the disease in an attempt at self-tolerance. The expected future results of such vaccines are promising.