Palladium-Catalysed Amide-Directed Ligand Free C8-Olefination of 1-Naphthamides for the synthesis of 2,3-dihydro-1H-benzo[de]isoquinolin-1-ones

This work describes the palladium(II)-catalyzed regioselective C8-H olefination of 1-naphthamides. Interestingly, naphthamide fused lactam 2,3-dihydro-1H-benzo[de]isoquinolin-1-one derivatives were also synthesized in the case of a particular class of napthamides. This protocol was found well compatible with a diverse range of acrylates and styrenes leading to product formation in good yields along with a wide functional group tolerance. The developed strategy was further applied to the synthesis of different drug derivatives.