Enantioselective Aldol Reaction with Difluoroenoxysilanes Catalyzed by Cationic Palladium Aqua Complexes
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
The enantioselective addition of difluoroenoxysilanes to aromatic aldehydes, catalyzed by cationic palladium aqua complexes, has been described. The reaction is operationally simple, does not require anhydrous conditions and performs at room temperature. The palladium catalysts, previously discovered and reported by Sodeoka, are easily prepared in two steps from PdCl2(MeCN)(2). The aldol compounds were obtained in good yields and with enantiomeric ratios up to 93 : 7, the reaction being more efficient using electron-rich aldehydes.
更多查看译文
关键词
aldol reaction,chiral ligands,enantioselectivity,fluorinated molecules,palladium catalysis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要