Gold-Catalyzed Redox-Neutral Reaction of Nitriles with Quinoline N-Oxides
ADVANCED SYNTHESIS & CATALYSIS(2023)
摘要
A method for the redox-neutral reaction of nitriles with quinoline N-oxides via gold catalysis is described. This transformation features a broad substrate scope and good functional group tolerance. A series of C2-amidated quinolines were synthesized in good to excellent yields under mild reaction conditions. Mechanistic studies suggested that the oxidative gold catalysis of nitriles might be initiated by the & sigma;-coordination of the gold catalyst with the N atom on nitrile, then the coordinated gold-nitrile intermediate is captured and oxidized by quinoline N-oxides.
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关键词
gold catalysis,nitrile,quinoline N-oxide,redox-neutral reaction,C-H functionalization
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