Modulatory effect of innervation on endometrial cancer

Research on cancer neurobiology has shown that the nervous system plays an important role in the initiation and progression of many types of cancer in humans, including breast, gastric, pancreatic, colorectal, and prostate cancers. Although endometrial cancer is not in the center of cancer neurobiology research, accumulating data indicate that sympathetic, parasympathetic, and sensory nerves innervating uterus modulate the initiation, progres-sion, and metastasis of endometrial cancer. However, compared to other types of cancer, data related to the role of nerves in endometrial cancer are sparse and inconsistent. Therefore, the aim of this review is to analyze available data related to physiological effects of nerves innervating uterus and endometrium and the modulatory effect of these nerves on endometrial cancer and to depict further research directions.