ASSOCIATION OF GENE POLYMORPHISM PTGS2 rs689466 WITH PLASMA IRISIN LEVEL IN YAKUTS

Prostaglandin E2 may be involved in an increase in body temperature during cold stress by the type of fever. At the same time, a significant part of heat production is produced during shivering thermogenesis, due to arbitrary muscle activity, which is accompanied by the release of the hormone irisin. Prostaglandin E2 is formed from arachidonic acid by the enzyme cyclooxygenase-2, which is encoded by the PTGS2 gene. The transcriptional activity of the PTGS2 gene depends on its allelic variants, which can affect thermoregulation processes in different ways. In this regard, the aim of this study is to analyze the polymorphism rs689466 of the PTGS2 gene with the level of irisin in blood plasma in a population of Yakuts living in cold climatic conditions. The study involved 183 women and 80 men (average age 19.73 +/- 1.99 years). Analysis of the association of polymorphism rs689466 of the PTGS2 gene with irisin levels showed that in men with the TT genotype, irisin levels (8.2 +/- 1.85 mu g/ml) were statistically significantly higher (U=261; p=0.005), compared with men with CT+CC genotypes (7.1 +/- 1.25 mu g/ml). In addition, it was found that men with the TT genotype (63.6 +/- 6.67 kg) had a lower weight than men with the CT+CC genotypes (67.93 +/- 7.28 kg; U=279; p=0.01). The detected association of the TT rs689466 genotype of the PTGS2 gene with elevated irisin levels and with a lower weight in men may indicate the effect of prostaglandin E2 on shivering thermogenesis during cold stress, which may play a role in human adaptation to a cold climate.