Healing Activity of the Lyophilized Hydroethanolic Extract of Piper Angustifolium in Guinea Pigs with Dermal Subcutaneous Lesions

Subcutaneous and dermal lesions in guinea pigs ( Cavia porcellus) are of clinical importance. However, their treatment has not been effective with traditional veterinary products. Therefore, the healing activity of the lyophilized hydroethanolic extract of Piper angustifolium at different concentrations was evaluated in guinea pigs with subcutaneous and dermal lesions, as well as the cost of treatment. Ninety-two six-month-old female guinea pigs of the Peruvian breed with subcutaneous and dermal lesions were used after clinical examination. The groups consisted of: G1-M 40 %, G2-M 70 %, G3 - CP and G4-CN. G1, G2 animals were treated with 40 % and 70 % concentration of ethanolic extract of matico and G3 gentian violet topically for 15 days. The G2 treatment showed effective healing at 10 days in relation to G1 and G3. Healing time and diameter showed significant differences (p<0.05), in G2 (0.04 +/- 0.1c) at 10 days of study, being inferior to G3 (0.80 +/- 0.1 a) and G1 (0.36 +/- 0.4c). The lowest cost/treatment (US dollar) was for G2 ($/ 1.80) with respect to G1($/ 2.5) and G3 ($/ 3.2). The 70 % lyophilized hydroethanolic extract of Piper angustifolium was effective in healing subcutaneous and dermal lesions in guinea pigs at a lower cost in relation to conventional treatments.