Thermodynamics of intermolecular interaction reactions of biomolecules in water and water-organic solvents

The paper summarizes the results of our own research into the formation of molecular complexes of cyclodextrins with biologically active polyphenol compounds in water-organic sol-vents, chemical equilibria in the solutions of hydrazones and Schiff bases and their metal complex-es in the solutions of DNA and proteins. It was found that an increase in the content of the non -aqueous component in the binary solvent leads to a decrease in the stability of molecular complex-es of cyclodextrins with polyphenols and a decrease in the exothermicity of their formation reac-tions. It has been shown that metal complexes in an aqueous buffer solution containing also DNA or protein dissociate, and the released cation and free ligand bind to the biomolecule.