Mathematical Optimization of the Betulonic Acid Extraction from Bark of Betula pendula Roth

The paper describes a one -step method for obtaining betulonic acid directly from birch bark, based on the use of the Jones reagent. The influence of the duration and liquid solid ratio (LSR) of the process on the yield of betulonic acid has been studied. By the method of mathematical optimization using full factorial experiment type 3(2) and the Statgraphics Centurion XVI software package, the optimal conditions were established to ensure the yield of betulonic acid of 15.9 wt.%: duration - 3.5 h, LSR - 15. The structure of betulonic acid obtained under optimal conditions was established by methods FTIR and NMR spectroscopy, composition - by elemental analysis.