MAPKERK Signalling Pathway to Explore the Mechanism of Action of Dexmedetomidine in Labour Analgesia and Its Effect on Pregnancy Outcome

Objective: Analysis of the MAPKERK signalling pathway to explore the mechanism of action of dexmedetomidine in labour analgesia and its effect on pregnancy outcome. Methods: Sixty-six pregnant women admitted to our hospital between March 2020 and January 2022 were divided into two clusters according to the different modes of anaesthesia, i.e., the control cluster and the study cluster, and were clinically observed after anaesthesia. Results: Before analgesia, none notable variation in Adr and Cor levels between the two clusters (P>0.05), while during the active period, full opening of the uterus and delivery of the fetus, Adr and Cor levels in the study cluster were bottom than those in the control cluster, and the variation was notable (P<0.05), with full opening of the uterus > active period > delivery period. The heart rate and mean arterial pressure were stable and none hypotension or respiratory depression. None notable variation in the Apgar scores of neonates at 1min and 5min (P>0.05); before analgesia, none notable variation in HR, SBP and DBP between the two clusters (P>0.05), while during the active period, the full opening of the uterus and fetal delivery, HR, SBP and DBP in the study cluster were bottom than those in the control cluster, and the variation was notable (P<0.05). The variation between the two clusters was not notable (P>0.05) before the analgesia, and the variation was notable (P<0.05) during the active period, the fully opened uterus and the delivery period. Conclusion: It was observed that the study cluster had notablely better blood pressure control during labour, spontaneous delivery and caesarean section rates than the control cluster. In conclusion, the use of dexmedetomidine notablely improved maternal distress and anxiety, exerted satisfactory analgesia and sedation, did not depress maternal breathing, did not affect the fetus, increased the rate of spontaneous delivery and improved the fetal Apgar score. The anaesthetic is effective, simple, safe and has potential social and economic value and warrants further clinical trials and researchHan X et al / Arch Clin Psychiatry. 2022;49(2):55-60