Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application

Laura Banaszkiewicz,Mateusz Kacper Woźniak,Michał Kaliszan,Agata Kot-Wasik

MICROCHEMICAL JOURNAL（2023）

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摘要

•GC–MS/MS-based method for the quantification of benzodiazepines and Z-hypnotic drugs.•Sensitive, specific, simple and fast GC–MS/MS-based method without derivatization.•Benzodiazepines and Z-hypnotic drugs in forensic and clinical toxicology.•Comparison of LC-MS/MS and GC–MS/MS in term of precision and accuracy for toxicology.

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关键词

Benzodiazepines,Forensic toxicology,GC–MS/MS,Liquid-liquid extraction,Whole blood samples,Z-drugs

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