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Hyper-CVAD versus dose-adjusted EPOCH as initial treatment for adults with acute lymphoblastic leukemia.

Lucas C Zarling,Philip A Stevenson,Lorinda A Soma,Christen H Martino,Mary-Elizabeth M Percival,Anna B Halpern,Cristina M Ghiuzeli,Pamela S Becker,Vivian G Oehler,Jason P Cooper,Johnnie J Orozco,Paul C Hendrie,Roland B Walter,Elihu H Estey,Ryan D Cassaday

European journal of haematology（2023）

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Abstract
Our findings support continued use of Hyper-CVAD for Ph- ALL but suggest that DA-EPOCH may be a reasonable alternative for Ph+ ALL. These data also highlight a potential role for DA-EPOCH in resource-limited settings or when more intense therapy is not feasible.
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Key words
acute lymphoblastic leukemia, adults, DA-EPOCH, Hyper-CVAD, induction chemotherapy
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