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Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Rosa Rodriguez-Fernandez,Felipe Gonzalez-Martinez,Jimena Perez-Moreno,Maria Isabel Gonzalez-Sanchez,Blanca Toledo del Castillo, Irene Mingueza de la Paz, Laura Diaz Pozo, Asuncion Mejias,Octavio Ramilo

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2023）

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Abstract
We analyzed the frequency, clinical impact and severity of respiratory syncytial virus (RSV) and SARS-CoV-2 coinfections in a single pediatric center between March 2020 and January 2023. Compared to single RSV infections, RSV/SARS-CoV-2 coinfections were uncommon (2.1%), occurred more frequently during circulation of omicron, and were associated with increased disease severity as defined by longer hospitalization and increased need for high-flow nasal cannula.
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Key words
bronchiolitis,RSV,COVID-19,epidemiology,coinfection,severity
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