Metformin shows anti-neoplastic properties by inhibition of oxidative phosphorylation and glycolysis in epidermolysis bullosa-associated aggressive cutaneous squamous cell carcinoma.

T Welponer,D D Weber,L Trattner,B Tockner,S Aminzadeh-Gohari, V Leb-Reichl,A Kaufmann,R Zauner,M Wimmer,V Wally,T K Felder,D Strunk,U Koller, J W Bauer,B Kofler,C Guttmann-Gruber,J Piñon Hofbauer

Journal of the European Academy of Dermatology and Venereology : JEADV（2023）

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Abstract

Our data indicate that metformin exerts anti-neoplastic properties in aggressive cSCCs that exhibit high-risk features by interfering with respiration and glycolytic processes.

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