Copper (II) Complex Immobilized on Magnetic Nanoparticles: Fe 3 O 4 @Dopamine-PO-CuBr 2 as New and Highly Efficient Nanocatalyst for Synthesis of N-aryl Sulfonamides

Molecules containing sulfonamide groups possess significant bioactivity in medicinal and pharmaceutical chemistry, showcasing valuable anti-bacterial and anti-parasitic properties. In recent years, the immobilization of metallic catalysts, including copper, palladium, nickel, and zinc, onto the surface of Fe3O4 nanoparticles modified with ligands, has emerged as an effective and captivating catalytic strategy for enhancing chemical reactions. In this study, we successfully fabricated a novel and highly efficient magnetically recoverable nanocatalyst [Fe 3 O 4 @Dopamine-PO-CuBr 2 ] by immobilizing CuBr 2 on magnetic Fe 3 O 4 nanoparticles coated with dopamine. This nanocatalyst was utilized for the synthesis of N-aryl sulfonamides via a convenient one-pot three-component reaction involving aryl boronic acids, aryl amines, and DABSO as the SO 2 source. The spectroscopic techniques employed thoroughly validated the successful preparation of the [Fe 3 O 4 @Dopamine-PO-CuBr 2 ] nanocomposite.Notably, our research adds significant scientific value by presenting a well-designed nanocatalyst that efficiently promotes the synthesis of N-aryl sulfonamides. The ease of recovery and reusability of the [Fe 3 O 4 @Dopamine-PO-CuBr 2 ] nanocatalyst, which maintained its catalytic efficiency for up to 8 cycles without any substantial loss, further emphasizes its practicality and sustainability.This study introduces a promising and eco-friendly approach to produce bioactive N-aryl sulfonamides using a magnetically recoverable nanocatalyst. The reported findings hold great potential in the field of medicinal and pharmaceutical chemistry, demonstrating a significant step forward in the development of innovative catalytic strategies. Graphical Abstract