Potential role of microRNA-503 in Icariin-mediated prevention of high glucose-induced endoplasmic reticulum stress.

Bao-Lin Su,Liang-Liang Wang,Liang-You Zhang,Shu Zhang,Qiang Li,Gang-Yi Chen

World journal of diabetes（2023）

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摘要

ICA reduced HG-mediated inhibition of cell viability, promotion of apoptosis, and ER stress in PRKs. These effects involved regulation of the miR-503/SIRT4 axis. These findings indicate the potential of ICA to treat DN, and implicate miR-503 as a viable target for therapeutic interventions in DN.

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关键词

Icariin, MicroRNA-503, Sirtuin 4, Endoplasmic reticulum stress, Diabetic nephropathy, Kidney damage

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