Metabolic signature and proteasome activity controls synovial migration of CDC42 hi CD14 + cells in rheumatoid arthritis.

Eric Malmhäll-Bah,Karin M E Andersson,Malin C Erlandsson,Sofia T Silfverswärd,Rille Pullerits,Maria I Bokarewa

Frontiers in immunology（2023）

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摘要

This study shows that the CDC42-related MetSig identifies the antigen-presenting CD14 cells that migrate to joints to coordinate autoimmunity. The accumulation of CD14 cells discloses patients perceptive to the JAKi treatment.

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关键词

Rho-GTPases, CD14(+) cells, synovia, arthritis, oxidative phosphorylation, proteasome

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