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Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity.

Alberto Moreno,Kelly Manning,Maryam I Azeem,Ajay K Nooka,Madison Ellis,Renee Julia Manalo,Jeffrey M Switchenko,Bushra Wali,Jonathan L Kaufman,Craig C Hofmeister,Nisha S Joseph,Sagar Lonial,Kavita M Dhodapkar,Madhav V Dhodapkar,Mehul S Suthar

bioRxiv : the preprint server for biology（2023）

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Abstract
We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
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Key words
antibodies,myeloma,sars-cov
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