Circulating Exosomes from Alzheimer's Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell.

Jiani Bei,Ernesto G Miranda-Morales,Qini Gan,Yuan Qiu,Sorosh Husseinzadeh, Jia Yi Liew,Qing Chang,Balaji Krishnan,Angelo Gaitas,Subo Yuan,Michelle Felicella,Wei Qiao Qiu,Xiang Fang,Bin Gong

Journal of Alzheimer's disease : JAD（2023）

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摘要

These findings highlight the significant role of circulating exosomes from AD patients in damaging adherens junctions of recipient BMECs, dependent on exosomal RNA.

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关键词

Alzheimer's disease, blood-brain barrier, 3D microvascular model, exosome, endothelial barrier dysfunction, fluidic AFM, VE-cadherin

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