Sirtuin 1 is a potential therapeutic candidate gene for fetal growth restriction via insulin-like 4.

Junya Kojima,Yidan Dai,Tomoo Suzuki,Masanori Ono,Hirotaka Nishi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians（2023）

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Abstract

SIRT1 and INSL4 are downregulated in the placenta of FGR, and INSL4 is regulated by SIRT1. These findings indicate that the SIRT1-INSL4 axis may be a potential therapeutic target for FGR.

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Key words

Fetal growth restriction, sirtuin 1, insulin-like 4, insulin-like growth factor

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