Recording of brain activity using multichannel, biocompatible organic electrochemical transistors in vivo.

In vivo recordings of brain activity are vital for diagnostic purposes and brain science research. Organic electrochemical transistors (OECTs) are one of the most promising candidates due to their excellent signal-to-noise ratio, mechanical flexibility, and biocompatibility. Here, we propose the engineering of a multichannel, biocompatible OECT array, that is capable of laminating onto soft tissues seamlessly, monitoring neuron firing with high spatiotemporal resolution. The successful demonstrations of this device to map micro-electrocorticography in the rat model in vivo, demonstrate the great potential of this technology for clinical applications, human-brain interfaces, metaverse, etc.