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Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 Group F virus following serial passage in humanized mice

James Z. Curlin,Kimberly Schmitt,Jared Morrison,Leila Remling-Mulder,Corina Valencia Tibbitts,Shelby O'Connor,Preston Marx,Ramesh Akkina

Journal of medical primatology（2023）

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Abstract
HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4 T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.
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<scp>hiv</scp>‐2,mice,virus,pre‐epidemic,genetic changes
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