Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice

Fenlian Ma,Aijun Chen,Lihong Yao,Hanchun Gao,Qian Zhang,Wenzhe Hou,Lishu Zheng

Virus research（2023）

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摘要

•First study to prepare human metapneumovirus virus like particle (HMPV VLP) in a baculovirus.•HMPV VLP induces specific immune responses and protective efficacy in mice.•Aluminum hydroxide adjuvant enhances above immunogenicity and protective efficacy.

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关键词

Human metapneumovirus,Virus-like particle,Immunogenicity,Protective efficacy

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