Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns

Psychiatry Research(2023)

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摘要
•The current longitudinal study examined the impact of continuous cannabis usage over 2-yearson relevant outcomes in individuals at clinical high risk (CHR) for psychosis.•A small, but unique subsample of high-risk participants continuously used recreational cannabis (N = 12).•Relative to those that did not use cannabis (N = 118), continuous use did not worsen attenuated positive and negative symptoms, neurocognitive performance, and social functioning levels.•Clinical symptoms improved over time for all three subgroups, even though the continuous users declined their antidepressant and antipsychotic usage over time, compared to occasional users (N = 40) and non-users.
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关键词
Clinical high risk for psychosis,Prevention,Cannabis
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