Effect of seasonal coronavirus immune imprinting on the immunogenicity of inactivated COVID-19 vaccination.

Di Yin,Zirong Han,Bing Lang,Yanjun Li,Guoqin Mai,Hongbiao Chen,Liqiang Feng,Yao-Qing Chen,Huanle Luo, Yaming Xiong,Lin Jing,Xiangjun Du,Yuelong Shu,Caijun Sun

Frontiers in immunology（2023）

Cited 4|Views19

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Abstract

We found a high prevalence of antibodies against sCoVs in Chinese population. The immune imprinting by sCoVs could be reactivated by COVID-19 vaccination, but it did not appear to be a major factor affecting the immunogenicity of COVID-19 vaccine. These findings will provide insights into understanding the impact of immune imprinting on subsequent multiple shots of COVID-19 vaccines.

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Key words

seasonal coronavirus,immunogenicity

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