CAR T cells ignite antitumor immunity.

Trends in immunology（2023）

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摘要

Broadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.

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关键词

chimeric antigen receptor (CAR),CAR T cell,vaccine,IFNgamma,myeloid cells,antigen spreading,tumor heterogeneity

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